HORDB

ID: hor002635
Uniprot ID: Q18915
Protein name: NLP-14
Gene name: nlp-14
Organism: Caenorhabditis elegans
Family: NA
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0071244 cellular response to carbon dioxide; GO:1903745 negative regulation of nematode pharyngeal pumping
GO CC: NA

Sequence: ALNSLDGQGFGFE
Length: 13
Propeptide: MLHLIVLLVALSSAVTAGRPRRALDGLDGSGFGFDKRALNSLDGAGFGFEKRALNSLDGQGFGFEKRALDGLDGAGFGFDKRALNSLDGAGFGFEKRALDGLDGSGFGFDKRALNSLDGAGFGFEKRALNSLDGAGFGFEKRALDGLDGAGFGFDKRALNSLDGAGFGFEKRALDGLDGAGFGFDKRALNSLDGNGFGFDKRTFKHSSNKLRSVFRNLKGFKQH
Signal peptide: MLHLIVLLVALSSAVTA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002635_AF2.pdb

hor002635_ESM.pdb

Mass:	156867	Formula:	C60H87N15O21
Absent amino acids:	CHIKMPRTVWY	Common amino acids:	G
pI:	3.55	Basic residues:	0
Polar residues:	5	Hydrophobic residues:	5
Hydrophobicity:	-7.69	Boman Index:	-1068
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	67.69
Instability Index:	853.85	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 20013198
Title: Approaches to Identify Endogenous Peptides in the Soil Nematode Caenorhabditis elegans